DNA Repair by I. Kruman

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By I. Kruman

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As with bacterial RtcAB, the biological role of the PnkP/Hen1 is not known. Noteworthy in this regard is that PnkP/Hen1 is most abundant among Actinobacteria. In contrast, RtcAB is more prevalent among Proteobacteria and has not been detected yet in Actinobacteria. This coincidence raises the possibility that the two systems provide similar benefits to their respective hosts. In theory, PnkP/Hen1 complexes could defend their host cells from secreted ribotoxins more efficiently than RtcAB due to the ability to prevent re-cleavage of the susceptible RNA.

54] Butala M, Zgur-Bertok D, Busby SJ. The bacterial LexA transcriptional repressor. Cell Mol Life Sci 2009;66(1):82-93. [55] Dorer MS, Fero J, Salama NR. DNA damage triggers genetic exchange in Helicobacter pylori. PLoS Pathog 2010;6(7):e1001026. [56] Cromie GA, Connelly JC, Leach DR. Recombination at double-strand breaks and DNA ends: conserved mechanisms from phage to humans. Mol Cell 2001;8(6):1163-74. [57] Kuzminov A. Recombinational repair of DNA damage in Escherichia coli and bacteriophage lambda.

This conserved bacterial protein was detected in quest of roles of two phage T4-encoded enzymes: 3'-phosphatase/5'-polynucleotide kinase (PseT/Pnk, Elena Davidov, Emmanuelle Steinfels-Kohn, Ekaterina Krutkina, Daniel Klaiman, Tamar Margalit, Michal Chai-Danino and Alexander Kotlyar Tel Aviv University, Israel * 22 DNA Repair henceforth Pnk) (Richardson, 1965;Becker & Hurwitz, 1967;Cameron & Uhlenbeck, 1977) and RNA ligase 1 (Rnl1, Silber et al, 1972;Ho & Shuman, 2002). The combined activities of Pnk and Rnl1 seemed tailored to fix RNA nicks, converting 3'-phosphoryl or 2',3'-cyclic phosphate and 5'-OH cleavage ends into 3'5' phosphodiester linkages (Kaufmann & Kallenbach, 1975;Amitsur et al, 1987).

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