DNA Methylation: Approaches and Applications by Manel Esteller

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By Manel Esteller

Knowing the complicated roles of DNA methylation is at the moment an energetic box of analysis. DNA Methylation: techniques and purposes provides the most up-tp-date study at the impression of DNA methylation in human illness, really melanoma. Written by means of leaders within the box, this state-of-art reference delineates the simplest innovations to exploit while addressing questions in regards to the cytocine methylation prestige of genomic DNA. It comprises ideas, experimental types, and scientific makes use of of demethylating brokers. The booklet offers a stability among articles clarifying methodological info and extra common overview chapters that supply large organic views on DNA methylation.

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V. , Quantitative GSTP1 methylation and the detection of prostate adenocarcinoma in sextant biopsies, J. Natl. , 95, 1634, 2003. 100. Etzioni, R. S. prostate cancer incidence trends, J. Natl. , 94, 981, 2002. fm Page 26 Thursday, August 5, 2004 8:33 AM 26 DNA Methylation: Approaches, Methods, and Applications 101. Maruyama, R. , Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features, Clin. , 8, 514, 2002. 102. C. , GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas, Int.

G. , Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands, Proc. Natl. Acad. Sci. USA, 93, 9821, 1996. 8. A. , MethyLight: a high-throughput assay to measure DNA methylation. , 28, E32, 2000. 9. A. , 6, 986, 1996. 10. Shapiro, B. , Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease, Cancer, 51, 2116, 1983. 11. Esteller, M. , 59, 67, 1999. 12. Sanchez-Cespedes, M. , 60, 892, 2000. fm Page 22 Thursday, August 5, 2004 8:33 AM 22 DNA Methylation: Approaches, Methods, and Applications 13.

113. Esteller, M. , Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma, J. Natl. , 94, 26, 2002. 114. Taniguchi, T. , Disruption of the Fanconi anemia-BRCA pathway in cisplatinsensitive ovarian tumors, Nat. , 9, 568, 2003. 32 A Molecular Link between X Inactivation and Genomic Imprinting? fm Page 28 Thursday, August 5, 2004 8:37 AM 28 DNA Methylation: Approaches, Methods, and Applications ACKNOWLEDGMENTS The authors gratefully acknowledge Mrs.

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