DNA Methylation and Complex Human Disease by Michel Neidhart

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By Michel Neidhart

DNA Methylation and complicated Human Disease stories the chances of methyl-group-based epigenetic biomarkers of significant ailments, adapted epigenetic treatments, and the long run makes use of of high-throughput methylome applied sciences.

This quantity contains many pertinent advances in disease-bearing examine, together with weight problems, variety II diabetes, schizophrenia, and autoimmunity. DNA methylation can also be mentioned as a plasma and serum try for non-invasive screening, diagnostic and prognostic assessments, in comparison to biopsy-driven gene expression research, elements that have ended in using DNA methylation as a possible device for selecting melanoma danger, and prognosis among benign and malignant disease.

Therapies are on the center of this quantity and the probabilities of DNA demethylation. In melanoma, not like genetic mutations, DNA methylation and histone variations are reversible and hence have proven nice capability within the race for potent remedies. moreover, the authors current the significance of high-throughput methylome research, not just in melanoma, but additionally in non-neoplastic ailments reminiscent of rheumatoid arthritis.

  • Discusses breaking biomarker examine in significant disorder households of present wellbeing and fitness drawback and study curiosity, together with weight problems, style II diabetes, schizophrenia, and autoimmunity
  • Summarizes advances not just proper to melanoma, but additionally in non-neoplastic illness, at the moment an rising field
  • Describes entirely new innovations, together with the linking of metabolic pathways with epigenetics
  • Provides translational researchers with the information of either uncomplicated study and health center functions of DNA methylation in human diseases

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Extra resources for DNA Methylation and Complex Human Disease

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J Immunol 2004;172:3652À61. [19] Sunahori K, Juang YT, Kyttaris VC, Tsokos GC. Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus. J Immunol 2011;186:4508À17. DNA METHYLATION AND COMPLEX HUMAN DISEASE REFERENCES 41 [20] Garaud S, Le Dantec C, Jousse-Joulin S, Hanrote-Saliou C, Saraux A, Mageed RA, et al. IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation. J Immunol 2009;182:5623À32.

2013;50: 33À7. [9] Fradin D, Le Fur S, Mille C, Naoui N, Groves C, Zelenika D, et al. Association of the CpG methylation pattern of the proximal insulin gene promoter with type 1 diabetes. PLoS One 2012;7:e36278. [10] Belot MP, Fradin D, Mai N, Le Fur S, Zelenika D, Kerr-Conte J, et al. CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset. PLoS One 2013;8:e68093. [11] Takami N, Osawa K, Miura Y, Komai K, Taniguchi M, Shiraishi M, et al. Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells.

12] Karouzakis E, Rengel Y, Jungel A, Kolling C, Gay RE, Michel BA, et al. DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts. Genes Immun 2011;12. [13] Nile CJ, Read RC, Akil M, Duff GW, Wilson AG. Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis Rheum 2008;58:2686À93. [14] Stanczyk J, Ospelt C, Karouzakis E, Filer A, Raza K, Kolling C, et al. Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation.

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