Cytotoxic T-Lymphocytes in Human Viral and Malaria by M. B. A. Oldstone (auth.), Michael B. A. Oldstone (eds.)

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By M. B. A. Oldstone (auth.), Michael B. A. Oldstone (eds.)

Cytotoxic T lymphocytes (CTL) regulate numerous viral infections in animals in response to deletion and reconstitution experiments with CTL clones and use of CD8 genetically poor (knock-out) mice. during this quantity, info for the position that CTL play in human infectious ailments is gifted. As such, this represents the 1st quantity within which such details from numerous assorted viral and protozoan infections is introduced together.

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Fels A. Polsky G, Castro-Malaspina H, Peppard JR. Bartus P, Hammerling U, O'Reilly RJ (1988) Cytomegalovirus pneumonia after bone marrow transplantation successfully treated with the combination of ganciclovir and high dose intravenous immune globulin. Ann Intern Med 109: 777 -782 32 S. R. Riddell and P. D. Greenberg Englund JA. Sullivan CJ, Jordan MC (1988) Respiratory syncytical virus infection in immunocompromised adults. Ann Intern Med 109: 203-208 Erice A. Chou SW, Biron K, Stanat SC, Balfour HH, Jordan MC (1989) Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients.

35 . . . . . . . . . . .. .. 39 39 45 47 . . . . . CTL . . . . . . . . . . . . .. .. 51 52 52 54 55 Conclusions......................................... 56 References . . . . . . . . . . . . . . . . . . . . . . 57 . . . . . . . . . . . Virus Type . . . . . 1 . . . . . . . . . . . Replication . . . . . . . by . 1 Introduction Following the identification of the human immunodeficiency virus type 1 (HIV-1) as the etiologic agent of acquired immunodeficiency syndrome (AI DS; BARRE-SINOUSSI et al.

1991). An exception to this restriction pattern is the circulating envelope-specific Cll response, which is mediated by both HlA class I-restricted and nonrestricted effector mechanisms (MCCHESNEY et al. The non-major histocompatibility complex (MHC)-restricted lysis of envelope-expressing targets is largely mediated by CD16-bearing lymphocytes (WEINHOLD et al. 1988; RIVIERE et al. 1989a). Although a recent report suggests the presence of Cll activity within freshly isolated CD4 lymphocytes as well as CD8 lymphocytes from infected subjects (KUNDU et al.

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