Chromatin and Disease (Subcellular Biochemistry) by Tapas K. Kundu, Dipak Dasgupta

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By Tapas K. Kundu, Dipak Dasgupta

This publication features a number of articles with the large subject of ailment connection to chromatin constitution and serve as. It elaborates at the molecular pharmacology of the medicine focusing on chromatin constitution and its elements. The publication includes updated information regarding the chromatin constitution and chromatin similar illnesses and drug capabilities. This paintings is the 1st pastime to give assorted features encompassing the above theme.

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Cell 64:137–148 Adolph KW, Kreisman LR, Kuehn RL (1986) Assembly of chromatin fibers into metaphase chromosomes analyzed by transmission electron microscopy and scanning electron microscopy. Biophys J 49:221–231 Agresti A, Bianchi ME (2003) HMGB proteins and gene expression. Curr Opin Genet Dev 13:170–178 Anderson DE, Losada A, Erickson HP, Hirano T (2002) Condensin and cohesin display different arm conformations with characteristic hinge angles. 1 A resolution: a tripartite protein assembly and a left-handed superhelix.

It is proposed that Sth1 binds to DNA at a fixed site inside the nucleosome, about two DNA helical turns off the dyad axis. The suggestion is that directional DNA translocation by Sth1 breaks histone-DNA contacts creating a DNA wave intermediate that then propagates to the distal entry/exit site by diffusion. However, in contrast to the related movements of DNA helicases, Sth1 remains anchored at the histone octamer at a position where the Histone H4 Nterminus passes between two gyres of nucleosomal DNA.

J Mol Biol 226:1009–1025 Gonsior SM, Platz S, Buchmeier S, Scheer U, Jockusch BM, Hinssen H (1999) Conformational difference between nuclear and cytoplasmic actin as detected by a monoclonal antibody. J Cell Sci 112(Pt 6):797–809 Goodwin GH, Sanders C, Johns EW (1973) A new group of chromatin-associated proteins with a high content of acidic and basic amino acids. Eur J Biochem 38:14–19 Goto H, Tomono Y, Ajiro K, Kosako H, Fujita M, Sakurai M, Okawa K, Iwamatsu A, Okigaki T, Takahashi T, Inagaki M (1999) Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation.

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