Cap-Analysis Gene Expression (CAGE): The Science of Decoding by Piero Carninci

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By Piero Carninci

A advisor for clients of recent applied sciences, this quantity comprises correctly confirmed protocols, permitting readers to arrange their samples for experiments. also, it offers a advisor for the bioinformatics instruments which are to be had for the research of the got tags, together with the layout of the software program, the assets and internet info the place they are often downloaded. ultimately, the ebook offers examples of the applying of those applied sciences to spot promoters, annotate genomes, establish new RNAs and reconstruct versions of transcriptional regulate. even if examples in general regard mammalians, the dialogue expands to different teams of eukaryotes, the place those techniques are complementing genome sequencing.

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Multiple PET clusters (339 PETs) with their 5’ tags mapped to chr20q13, the starting region of BCAS4 gene whereas the 3’ tags mapped to chr17q23, the 3’ terminal region of BCAS3 gene. The resulted fusion transcript is 1177 bp. Bottom: Two different fusion genes derived from trans-splicing events in mouse embryonic stem cells. ch04 49 September 16, 2009 50 15:22 RPS: Pan Stanford Publishing Book - 6in x 9in Transcriptome and Genome Characterization fundamental questions can be addressed through whole genome comprehensive profiling of the transcription factor DNA interactions and characterization of chromatin structures mediated by specific transcription factor interactions.

Antisense transcription in the mammalian transcriptome. Science 309, 1564–1566 (2005). [6] P. Carninci, J. Yasuda & Y. Hayashizaki. Multifaceted mammalian transcriptome. Curr. Opin. Cell. Biol. 20, 274–280 (2008). [7] A. Sandelin et al. Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nat. Rev. Genet. 8, 424–436 (2007). [8] Y. Suzuki et al. Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res. 11, 677–684 (2001).

6] P. Carninci, J. Yasuda & Y. Hayashizaki. Multifaceted mammalian transcriptome. Curr. Opin. Cell. Biol. 20, 274–280 (2008). [7] A. Sandelin et al. Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nat. Rev. Genet. 8, 424–436 (2007). [8] Y. Suzuki et al. Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res. 11, 677–684 (2001). [9] V. E. Velculescu, L. Zhang, B. Vogelstein and K. W. Kinzler. Serial analysis of gene expression.

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