Cancer stem cells : the cutting edge by Stanley Shostak

Posted by

By Stanley Shostak

Show description

Read Online or Download Cancer stem cells : the cutting edge PDF

Similar cancer books

The Middle Place

For Kelly Corrigan, family members is every little thing. At thirty-six, she had a wedding that labored, humorous, energetic teenagers, and a weekly newspaper column. yet at the same time a thriving grownup, Kelly nonetheless observed herself because the daughter of garrulous Irish-American charmer George Corrigan. She used to be residing deep inside of what she calls the center Place--"that sliver of time while parenthood and early life overlap"--comfortably wedged among her grownup tasks and her parents' care.

Breast Cancer and the Post-Surgical Body: Recovering the Self

An exam of surgical breast reconstruction which establishes a powerful hyperlink among, at the one hand, the non-public emotions and activities of ladies with breast melanoma, and at the different, robust discourses and practices of the breast melanoma circulation.

Additional info for Cancer stem cells : the cutting edge

Example text

BMC Cancer, 9, 202. ; Ginestier, C. & Birnbaum, D. (2010). Cancer stem cells: just sign here! Cell Cycle, 9, 2, pp. 229-30. ; Birnbaum, D. S. (2008). Cancer stem cells in breast: current opinion and future challenges. Pathobiology, 75, pp. 75-84. W. et al. (2010). Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGFinduced glioma cells. Cell Stem Cell, 6, 2, pp. 141-152. ; Howell, A. S. (2003). Regulation of human breast epithelial stem cells. Cell Proliferation, 36, Suppl 1, pp.

In a study performed in human breast cancer, the high expression of Notch intracellular domain in ductal carcinoma in situ (DCIS) has been shown to correlate with reduced disease-free survival time at five years after surgery (Farnie & Clarke, 2007). , 2010). Oncogenic or tumour suppressor genes, such as HER-2, PTEN and p53, have also been implicated in the regulation of CSC self-renewal. These genes are usually impaired in CSCs, 18 Cancer Stem Cells - The Cutting Edge leading to uncontrolled self-renewal, which in turn can generate resistant tumours in relation to current therapeutic approaches.

Thus, the CSC model suggests that tumour progression, metastasis and recurrence after therapy can be driven by a rare subgroup of tumoural cells that have the capacity to self-renew, while the bulk of the tumour does not have this capacity. Therefore, the deregulation of this self-renewal process leading to stem cell expansion may be a key event in carcinogenesis, and while self-renewal can drive tumorigenesis, the differentiation process may contribute to tumour phenotypic heterogeneity (Kakarala & Wicha, 2008; Shay & Wright, 2010).

Download PDF sample

Rated 4.94 of 5 – based on 33 votes