Cancer Immunotherapy: Paradigms, Practice and Promise by Tyler J. Curiel (auth.), Tyler J. Curiel (eds.)

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By Tyler J. Curiel (auth.), Tyler J. Curiel (eds.)

This paintings will offer a ancient viewpoint on tumor immunotherapy, talk about basic mechanisms of failed tumor rejection, examine passive ideas to spice up anti-tumor immunity, in addition to have an in-depth examine lively options to spice up anti-tumor immunity.

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Marturano J, Longhi R, Russo V, Protti MP (2008) Endosomal proteases influence the repertoire of MAGE-A3 epitopes recognized in vivo by CD4+ T cells. Cancer Res 68:1555–1562 71. Tatsumi T, Kierstead LS, Ranieri E, Gesualdo L, Schena FP, Finke JH, Bukowski RM et al (2002) Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma. J Exp Med 196:619–628 72. Slager EH, Borghi M, van der Minne CE, Aarnoudse CA, Havenga MJ, Schrier PI, Osanto S et al (2003) CD4+ Th2 cell recognition of HLA-DR-restricted epitopes derived from CAMEL: a tumor antigen translated in an alternative open reading frame.

Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057–1061 2 T Cell and Antigen-Presenting Cell Subsets in the Tumor Microenvironment 37 105. Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4:330–336 106. Khattri R, Cox T, Yasayko SA, Ramsdell F (2003) An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 4:337–342 107.

B cells can additionally mediate immunosuppressive functions via their cytokine products. The immunoregulators IL-10 and TGF-b can both be produced by B cells246 and foster downregulation of antigen presentation, suppression of T cell activation, and maintenance of Treg 2 T Cell and Antigen-Presenting Cell Subsets in the Tumor Microenvironment 31 suppressor function247–249. However, we have recently demonstrated several new roles for IL-10 in support of antitumor immunity, including the moderation of tumor-associated suppressive cellular networks including regulatory T cells and myeloid-derived suppressor cells250.

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