Breast Cancer 4: Advances in Research and Treatment by Robert B. Livingston (auth.), William L. McGuire M.D. (eds.)

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By Robert B. Livingston (auth.), William L. McGuire M.D. (eds.)

This is the fourth e-book in a chain facing breast melanoma. Volumes 1-3 have been occupied with therapy, experimental biology, and a few diversified well timed subject matters. the current quantity maintains to study the breast melanoma box within the broadest feel. the 1st bankruptcy addresses the query of choosing acceptable chemotherapy for the sufferer. within the Seventies, nice advances have been obvious in our skill to accomplish goal tumor regression with empirical combina­ tions of chemotherapeutic brokers. the following decade will specialise in targeted tips on how to choose these brokers prone to have the best profit in person sufferers. Livingston has supplied us with a radical evaluation of the present cutting-edge. we've got identified for it slow that steroid hormone receptor assays of substantial worth to clinicians taking care of sufferers with complicated illness. Osborne and associates now current huge arguments that receptor assays also are necessary within the surroundings of fundamental breast melanoma for reasons of either diagnosis and therapy procedure. a vital scientific challenge which has acquired little cognizance within the learn laboratory is benign breast ailment. If one inquires concerning the clinical treatment of this disease within the usa, it truly is noticeable that almost all of physicians might savour a greater figuring out of the pathophysiology which would bring about better remedies. Mauvais-Jarvis and associates offer us with such an account from their broad experience.

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Alberts, and T. Moon, Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs, N. EngI. J. Med. 298, 1321-1328 (1978). 59. S. Salmon, B. Soehnlen, B. Durie, D. Alberts, F. Meyskens, H. Chen, and T. Moon, Clinical correlations of drug sensitivity in tumor stem cell assay, Proc. Am. Assoc. Cancer Res. 20, 340 (1979). 60. D. Von Hoff, Initial experience with stem cell assay, in: Proceedings of the Human Tumor Colony Conference (S. ), Alan Liss, New York (in press) (1979).

44 C. K. Osborne et al. Data from several other centers have now confirmed our results. Preliminary studies by DeSombre et al. (24) and Rich et al. (25) have found a shorter disease-free interval and more recurrences in ER-negative patients, though these studies do not address whether the effect of ER is independent of other variables. Allerga et al. (26)have reported a more thorough study and have found a relationship between ER status and disease-free interval that is strikingly similar to our own data.

Carey, In vitro assay for human breast cancer hormone responsiveness, Oncology 29, 470-483 (1974). S. Nordqvist, In vitro effects of progression of DNA synthesis in metastatic endometrial carcinoma, Gynecol. Oncol. 2,415-429 (1974). M. Lippmann, R. Halterman, B. Leventhal, S. Perry, and E. Thompson, Human acute lymphoblastic leukemic cells, f. CZin. Invest. 52, 1715-1725 (1973). G. Dosik, B. Bariogie, D. Johnston, D. Mellard, and E. Freireich, In vitro drug sensitivity test to predict clinical response in acute myeloblastic leukemia (submitted) (1980).

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