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Additional resources for Bioinformatics and Functional Genomics
1, 251– 279 (2000). , Lee, S. , Kim, Y. , and Kim, S. Bioinformatics in the post-genome era. J. Biochem. Mol. Biol. 37, 75– 82 (2004). Chapter 2 introduces ways to access molecular data, including information about DNA and proteins. One of the first scientists to study proteins was Iacopo Bartolomeo Beccari (1682 – 1776), an Italian philosopher and physician who discovered protein as a component of vegetables. This image is from page 123 of the Bologna Commentaries, published in 1745 and written by a secretary on the basis of a 1728 lecture by Beccari.
From RNA we turn to consider proteins from the perspective of protein families, and the analysis of individual proteins (Chapter 10) and protein structure (Chapter 11). We conclude the middle part of the book with an overview of the rapidly developing field of functional genomics (Chapter 12). Since 1995, the genomes have been sequenced for several thousand viruses, prokaryotes (bacteria and archaea), and eukaryotes, such as fungi, animals, and plants. The third section of the book covers genome analysis (Chapters 13 to 20).
BIOINFORMATICS : THE BIG PICTURE 7 genes and proteins derived from different tissues and conditions. One of the most powerful applications of functional genomics is the use of DNA microarrays to measure the expression of thousands of genes in biological samples. At the largest scale is the tree of life (Fig. 3) (Chapter 13). There are many millions of species alive today, and they can be grouped into the three major branches of bacteria, archaea (single-celled microbes that tend to live in extreme environments), and eukaryotes.