Bioactive Carbohydrate Polymers by H. Wagner, S. Kraus (auth.), Berit S. Paulsen (eds.)

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By H. Wagner, S. Kraus (auth.), Berit S. Paulsen (eds.)

Bioactive Carbohydrate Polymers is without doubt one of the first ebook facing the newest within the box of polysaccharides and similar items and their organic actions, specially the immunological results. the several chapters describe the constitution and bioactivity of polysaccharides from crops utilized in conventional drugs in several elements of the area, in particular China, Japan and Europe. the focal point of the booklet is on immunologically energetic plant and seaweed polysaccharides, pharmacological actions of sulphated polysaccharides of animal and seaweed foundation, and on attainable actions of polysaccharides in our meals. tools for isolation and characterisation of the polymers with chemical and enzymatic tools is roofed, in addition to discussions at the varied organic test-systems and the knowledge they supply.
This e-book can be invaluable to scientists and postgraduate scholars operating with polysaccharides and their attainable makes use of, and will be of curiosity for individuals operating within the components of chemistry, biology, pharmacy and medicine.

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These non-cytotoxic galactan structures are further developed as angiogenesis inhibitor lead-structures. 1 Introduction During the past decade many significant developments in the utilization of carbohydrate polymers as drugs have been put forward. This, however, is not surprising since it is known that many of these biopolymers play an essential role in key biological processes. Some of the new fields of polysaccharide applications have been approved by the scientific world, others are still a matter of controversies and hence are not being accepted for clinical approval [1].

Over-activation of the complement system has been shown to contribute to the etiology of many inflammatory diseases, including rheumatoid arthritis, asthma, adult respiratory distress syndrome and systemic lupus erythematosus (7). Compounds exhibiting anti-complementary effects would therefore be of potential interest as aids in the treatment of such diseases. Even at the lower concentration (100 f,lg/ml) all fractions showed considerable reduction of 32 Chapter 3 complementary-induced hemolysis, ranging from 49-85% (6).

This was confirmed by the multiple signals appearing in the C-1 and C-S regions of Xylp [6]. (l~3)- Table 6. Chemical shift assignments for the J3C NMR spectra ofheteroxylan fraction C from the seeds of Plantago major L. [6]. 1 M TF A. Fractions were isolated by HPAEC and analysed by total hydrolysis, methylation, GC-MS, ES-MS and ES-MS/MS [7]. p. 2 and 6-11 were identified from the isolated fractions. This showed that the backbone of the molecule consisted of blocks of (1~4)-linked Xylp and (l~3)-linked Xylp, respectively.

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