Antimicrobial agents : antibacterials and antifungals by André Bryskier

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By André Bryskier

Annotation Antimicrobial brokers: Antibacterials and Antifungals is an important revision of an unique French reference released via Ellipses in 1999. bargains thousands of antibiotics and antimicrobial compounds: in improvement, experimental, and in useProvides an intensive replace of the unique French variation released in 1999, plus severe new materialPresents accomplished assurance of chemistry and synthesis, Read more...


Antimicrobial brokers: Antibacterials and Antifungals is an important revision of an unique French reference released by means of Ellipses in 1999. Read more...

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G. F. Newton and Edward Abraham discovered a third metabolite, cephalosporin C, that possessed only 10% of the activity of penicillin N. It attracted the attention of researchers at Oxford University because it was much more stable in an acidic medium than penicillin N and because of its greater resistance to hydrolysis by the penicillinase produced by Bacillus subtilis. In addition, it was atoxic in mice, and in vivo it protected mice infected with penicillin G-resistant strains of staphylococci and streptococci.

They noted that the filtrate of a 4-week culture of P. aeruginosa, evaporated, dialyzed, precipitated with alcohol, and redissolved in water, destroyed certain microorganisms, such as streptococci, staphylococci, and the diphtheria bacillus. They called this substance pyocyanase; it might be considered the first antibiotic from a historical point of view. Pyocyanase was used by Fortineau in the treatment of anthrax. A number of studies have been devoted to antibiosis. In 1885, A. V. Cornil and Victor Babes postulated that the origin of this antagonism was a substance produced by one microorganism that inhibited the growth of another.

Cephalosporins exhibiting antistaphylococcal activity against strains resistant to methicillin have been produced and are currently under development. 10. 8. , those producing cephalosporinases) and against streptococci, pneumococci, H. influenzae, and M. catarrhalis. However, these drugs are moderately active against oxacillin-susceptible strains of S. aureus and also against P. aeruginosa. The search for orally absorbable antibiotics of the ␤-lactam family that are not destroyed by gastric acidity has resulted in the synthesis of the phenoxypenicillins.

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