Antifolate Drugs in Cancer Therapy by Robert C. Jackson (auth.), Ann L. Jackman (eds.)

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By Robert C. Jackson (auth.), Ann L. Jackman (eds.)

In Antifolate medications in melanoma remedy, Ann Jackman and a panel of very popular researchers comprehensively overview the present prestige of novel antifolates, a big category of anticancer medicinal drugs. the celebrated individuals talk about the preclinical and scientific pharmacology of methotrexate, different dihydrofolate reductase inhibitors,
5-fluorouracil, and the recent new release of antifolates-the thymidylate synthase and glycinamide ribonucleotide formyltransferase inhibitors. furthermore, they evaluate intensive the modulation of antifolate medicines, folate and antifolate shipping mechanisms, polyglutamation, resistance, and drug combos, in addition to pharmacogenomics, pharmacodynamics, rules of gene expression, and mechanisms of telephone demise.

The large and revolutionary scope of Antifolate medicines in melanoma remedy offers entré to fascinating new avenues for destiny study, and constitutes a brand new ordinary reference for all simple scientists and clinicians engaged in melanoma therapeutics.

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