By Joseph F. Albright
George Washington Univ. institution of medication, Washington, D.C. Examines the foremost positive factors and services of the immune procedure probably to be altered by means of the getting older method. reports the sluggish breakdown of the resistance to an infection within the elderly and discusses lifespan extension and dietary hold up of immunosenescence. DNLM: Immunity--Aged.
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This can be a 3-in-1 reference publication. It offers a whole scientific dictionary masking enormous quantities of phrases and expressions with regards to Listeria monocytogenes. It additionally provides huge lists of bibliographic citations. eventually, it offers details to clients on tips on how to replace their wisdom utilizing a variety of net assets.
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Additional resources for Aging, Immunity, and Infection
Monocytogenes is cell mediated and involves both activated phagocytic cells, especially IFN-γactivated macrophages, and cytotoxic T cells (see Chapters 3 and 4). Foci of infection may be seen in various organs, such as the liver and spleen where they appear as granulomas. One of the early reports that aged animals are more susceptible to infections than young adults, was a study of L. monocytogenes in mice (22). When mice were inoculated intravenously with a moderate number of L. monocytogenes, the course of infection was similar in young and old animals as judged by the numbers of bacteria in livers and spleens.
The common use of antibiotics in veterinary medicine and in agriculture has contributed to the problem to an extent that is difficult to determine but likely to be considerable. Geriatric medicine has certainly contributed to the growing problem of microbial antibiotic resistance. As a group, elderly patients in hospitals and long-term care facilities (LTCFs) are the major recipients of antibiotics. It has been estimated that among residents of LTCFs approx 40% of prescribed drugs for systemic use are antibiotics (68).
The wide variety of glycoconjugates with which bacterial lectins interact is shown in Table 2-4. That variety ensures the ability of many enteric bacteria to adhere at optimum sites and niches within the intestine. Intestinal E. coli strains can be categorized into several types depending on their attachment and invasive properties. Those categorized as enteropathogenic E. coli (EPEC) adhere to gut epithelial cells through intimin molecules. The latter are ligands for the bacterial complementary receptor known as Tir (translocated intimin receptor) (44,45).