Advancing Prion Science: Guidance for the National Prion by Institute of Medicine, Medical Follow-Up Agency, Committee

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By Institute of Medicine, Medical Follow-Up Agency, Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Laura B. Sivitz, Rick Erdtmann

Provides a record from the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies recommending examine to shut major gaps in current wisdom of prion illnesses and strategies for strengthening the U.S. learn infrastructure for learning those ailments. Softcover. DNLM: Prion ailments, prevention & control--United States.

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Fischer JR, Nettles VF. 2003. National chronic wasting disease surveillance in free-ranging cervids: accomplishments and needs. Proceedings of the 106th Annual Meeting of the United States Animal Health Association. St. Louis, MO: United States Animal Health Association. FSIS (Food Safety and Inspection Service). 2002. 3: Advanced Meat Recovery Using Beef Vertebral Raw Materials. [Online]. usda. htm [accessed July 2003]. FSIS. 2003. USDA Begins Sampling Program for Advanced Meat Recovery Systems.

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356(1406):197–200; Discussion 200– 202. CDC (Centers for Disease Control and Prevention). 1999. Ten great public health achievements in the 20th century. Morbidity and Mortality Weekly Report 48(12):241–244. CWD Task Force. 2002. Plan for Assisting States, Federal Agencies, and Tribes in Managing Chronic Wasting Disease in Wild and Captive Cervids. [Online]. html [accessed March 24, 2003]. Enari M, Flechsig E, Weissmann C.

The committee believes basic research in these four areas will supply the knowledge required to advance TSE diagnostics more quickly than applied research alone. The report text describes specific gaps in knowledge that need to be filled in each of the four areas. For instance, present models of prion conformation and tertiary structure are neither complete nor conclusive. Defining the structural differences between PrP isoforms could enable scientists to synthesize a PrPSc-specific antibody probe or aptamer.

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